Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Continuous-processing related ERPS in schizophrenic and normal children

R J Strandburg1, J T Marsh, W S Brown

  • 1Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles.

Biological Psychiatry
|April 15, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bi-national outbreak of <i>Salmonella</i> Newport infections linked to onions: the United States experience.

Epidemiology and infection·2022
Same author

Multistate outbreak of <i>Salmonella</i> Poona infections associated with imported cucumbers, 2015-2016.

Epidemiology and infection·2019
Same author

The effect of thermal processing on the behaviour of peanut allergen peptide targets used in multiple reaction monitoring mass spectrometry experiments.

The Analyst·2016
Same author

Relationship between 24-Hour Ambulatory Blood Pressure and Cognitive Function in Healthy Elderly People.

Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition·2014
Same author

The prevention and treatment of postoperative lymphedema of the arm.

Annals of surgery·2010
Same author

The first use of chloroform in surgery.

British medical bulletin·2010
Same journal

Neuroimaging of Heterogeneity in Neuropsychiatric Disorders: Toward Disease Progression Modeling.

Biological psychiatry·2026
Same journal

Impact of Transcranial Direct Current Stimulation-Induced Electric Fields on Slowing Cognitive Decline in Older Adults With Mild Cognitive Impairment or Remitted Major Depressive Disorder: An Analysis of the PACt-MD Randomized Clinical Trial.

Biological psychiatry·2026
Same journal

Remembering Jon-Kar Zubieta, M.D., Ph.D.

Biological psychiatry·2026
Same journal

Kappa opioid receptor availability in borderline personality disorder: An in-vivo investigation with [<sup>11</sup>C]EKAP PET imaging.

Biological psychiatry·2026
Same journal

From Satiety to Substance Use: Neural Mechanisms of GLP-1 Signaling in Appetite and Reward.

Biological psychiatry·2026
Same journal

Distinct and Shared Molecular Mechanisms Underlie Morphological-Functional Overcoupling and Undercoupling in Major Depressive Disorder.

Biological psychiatry·2026
See all related articles

Schizophrenic children show distinct event-related potential (ERP) abnormalities during the continuous performance task (CPT), indicating deficits in attentional resource allocation and information processing control.

Area of Science:

  • Neuroscience
  • Child Psychology
  • Psychiatric Disorders

Background:

  • The continuous performance task (CPT) is a validated tool for assessing attentional deficits.
  • Schizophrenia is associated with significant cognitive impairments, including attention.
  • Event-related potentials (ERPs) offer insights into the neural underpinnings of cognitive processes.

Purpose of the Study:

  • To investigate event-related potential (ERP) differences between schizophrenic and normal children during CPT performance.
  • To identify specific ERP abnormalities associated with schizophrenic impairments in attention and information processing.

Main Methods:

  • Multichannel electroencephalography (EEG) was used to record ERPs from schizophrenic and normal children.
  • Participants performed easy and hard versions of the continuous performance task (CPT).

Related Experiment Videos

  • Analysis focused on ERP components related to target detection, resource allocation, and maturation.

    • Main Results:

    • Schizophrenic children exhibited poorer CPT performance (fewer hits, more false alarms, longer reaction times).
    • Abnormal ERPs included a lack of expected negativity increase to targets, altered P3 amplitude distribution, a persistent parietal negativity, and absent right-lateralized P1/N1 components.
    • These ERP findings suggest failures in early attentional allocation, later strategic resource management, and potential maturational lags.

    Conclusions:

    • Schizophrenic children demonstrate widespread ERP abnormalities across multiple stages of information processing during the CPT.
    • These deficits reflect difficulties in the control and strategic allocation of cognitive resources.
    • ERP measures provide objective biomarkers for cognitive dysfunction in childhood schizophrenia.