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Updated: Aug 2, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
[Are antibiotics correctly prescribed in primary care?]
L Solsona Díaz1, M P Wennberg Rutlant, M Mata Cases
1Centro de Atención Primaria La Mina, Sant Adrià de Besòs, Barcelona.
Antibiotic prescriptions in primary care largely align with guidelines. However, treatment suitability was lower for acute bronchitis cases without risk factors, highlighting the need for objective analysis in medication use studies.
Area of Science:
- Primary Care Medicine
- Infectious Diseases
- Pharmacology
Context:
- Study conducted at La Mina Primary Care Centre, Barcelona.
- Prospective observational study design.
- Data collected from patients over 14 years old between June 1991 and May 1992.
Purpose:
- To identify antibiotic prescriptions for infectious conditions.
- To evaluate the suitability of prescribed antibiotics in a primary care setting.
Summary:
- Out of 474 patients with infections, antibiotics were prescribed in 206 cases (43.3%).
- Amoxicillin was the most frequently prescribed antibiotic (41.5%).
- Overall treatment suitability was 86.3%, with 56.5% deemed unnecessary and 29.7% necessary and appropriate.
Impact:
- Antibiotic prescribing generally follows primary care recommendations.
- Less suitable antibiotic treatment was noted for acute bronchitis cases lacking risk factors.
- Emphasizes the importance of objective criteria for qualitative analysis of medication use.
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