Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Progressive vaccinia: immunological aspects and transfer factor therapy

L Timár, J Budai, G Nyerges

    Infection
    |January 1, 1978
    PubMed
    Summary

    Progressive vaccinia, a severe smallpox vaccine complication, is linked to immune deficiencies. This case study highlights the limited efficacy of various treatments, including transfer factor therapy, in a patient with combined immune deficiency.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Ellipsometric Analysis of Aligned Carbon Nanotubes for Designing Catalytic Support Systems.

    Journal of nanoscience and nanotechnology·2018
    Same author

    The bifactor model of the Maslach Burnout Inventory-Human Services Survey (MBI-HSS)--an alternative measurement model of burnout.

    Stress and health : journal of the International Society for the Investigation of Stress·2013
    Same author

    An assessment of simple referee methods for the prediction of lean in pig carcasses.

    Meat science·2011
    Same author

    Muscular dystrophies: diagnostic approaches in Hungary.

    Acta physiologica Hungarica·2008
    Same author

    Premenstrual exacerbation in calcium ATPase disorders of the skin.

    Journal of the European Academy of Dermatology and Venereology : JEADV·2007
    Same author

    CYLD mutations underlie Brooke-Spiegler, familial cylindromatosis, and multiple familial trichoepithelioma syndromes.

    Clinical genetics·2006

    Area of Science:

    • Immunology
    • Vaccinology
    • Clinical Medicine

    Background:

    • Progressive vaccinia is a rare but severe complication following smallpox vaccination.
    • Underlying immune dysfunction is often present in patients with progressive vaccinia.
    • Immuno-correction strategies are explored for potential therapeutic benefits.

    Purpose of the Study:

    • To investigate the immunological profile of a patient with progressive vaccinia.
    • To evaluate the therapeutic efficacy of different treatment modalities, including immunoglobulins, antivirals, and transfer factor therapy.
    • To determine the underlying immune deficiency in a fatal case of progressive vaccinia.

    Main Methods:

    • Repeated assessment of humoral and cell-mediated immunity throughout the disease course.

    Related Experiment Videos

  • Administration of human antivaccinia immunoglobulin and N-methylisatin beta-thiosemicarbazone.
  • Application of non-specific and specific transfer factor preparations.
  • Autopsy to identify pathological findings.

    • Main Results:

    • The patient exhibited a partial deficiency in cell-mediated immunity.
    • Human antivaccinia immunoglobulin and N-methylisatin beta-thiosemicarbazone showed no therapeutic effect.
    • Non-specific transfer factor provided temporary clinical improvement.
    • Specific transfer factor therapy administered late in the disease course was ineffective.
    • Autopsy revealed findings consistent with combined immune deficiency.

    Conclusions:

    • Progressive vaccinia can be associated with combined immune deficiency.
    • Current therapeutic interventions, including transfer factor therapy, may have limited efficacy in severe cases.
    • Further research into effective treatments for immune deficiencies underlying progressive vaccinia is warranted.