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Chronic lymphoproliferative disorders: classification and diagnosis

C E Litz1, R D Brunning

  • 1Laboratory Medicine and Pathology, University of Minnesota Medical School, University of Minnesota Hospital, MN 55455.

Bailliere'S Clinical Haematology
|December 1, 1993
PubMed
Summary

Chronic lymphoproliferative disorders exhibit diverse characteristics but share common T, B, or natural killer cell immunophenotypes. Some lymphocytic proliferations remain unclassified due to unique features.

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Area of Science:

  • Hematology
  • Oncology
  • Immunology

Background:

  • Chronic lymphoproliferative disorders are a heterogeneous group of diseases.
  • These disorders involve abnormal proliferation of lymphocytes.

Purpose of the Study:

  • To describe the morphological, immunological, and clinical heterogeneity of chronic lymphoproliferative disorders.
  • To outline the classification of B-cell and T-cell chronic lymphoproliferative disorders.
  • To address the classification of unclassifiable lymphocytic proliferations.

Main Methods:

  • Morphological analysis of lymphoid cells.
  • Immunophenotypical characterization of cell surface markers.
  • Clinical evaluation of patient data.

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Main Results:

  • Common features include T, B, or natural killer cell immunophenotypes and terminal deoxy-nucleotidyl transferase negativity.
  • Specific B-cell disorders include B-chronic lymphocytic leukemia, hairy cell leukemia, and others.
  • T-cell disorders include prolymphocytic leukemia, adult T-cell leukemia-lymphoma, and others.

Conclusions:

  • Chronic lymphoproliferative disorders are diverse, with distinct B-cell and T-cell subtypes.
  • Some lymphocytic proliferations do not fit established criteria and remain unclassified.