Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Protein levels and plasmapheresis intensity

T S Ciszewski1, S Ralston, D Acteson

  • 1Canadian Red Cross Society, Blood Transfusion Service, Ontario, Canada.

Transfusion Medicine (Oxford, England)
|March 1, 1993
PubMed
Summary

Frequent, high-volume plasma donation (500-600 ml weekly) may lower total protein and IgG levels but remains safe for donors. Levels typically recover, showing minimal long-term impact on immunoglobulin concentrations.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pain after osteoporotic fractures using mouse models and patient samples.

Journal of bone and mineral metabolism·2025
Same author

The relationship between obesity and fractures.

Injury·2019
Same author

A snapshot of biologic drug development: Challenges and opportunities.

Human & experimental toxicology·2015
Same author

Management of glucocorticoid-induced osteoporosis.

Calcified tissue international·2012
Same author

The use of the placenta in human biochemical genetics with special reference to twin placentation and zygosity [summary].

Proceedings of the Royal Society of Medicine·2010
Same author

Prevention of Rh Immunization Due to Large Volumes of Rh-positive Blood.

British medical journal·2010

Area of Science:

  • Immunology
  • Transfusion Medicine
  • Biochemistry

Background:

  • Plasmapheresis is a common procedure for plasma donation.
  • Understanding the impact of donation intensity on donor health is crucial.

Purpose of the Study:

  • To evaluate the influence of plasmapheresis intensity on donor serum total protein and immunoglobulin concentrations.
  • To assess the safety and impact of frequent, high-volume plasma donation.

Main Methods:

  • Monthly measurement of total protein and immunoglobulins (IgG, IgA, IgM) in two plasma donor groups and a whole blood donor control group over 6 months.
  • Group one donated 500-600 ml plasma weekly; other groups donated less frequently (≥14 days).

Main Results:

Related Experiment Videos

  • Donors giving 500-600 ml weekly showed significantly lower average total protein and IgG levels (P < 0.002), though still within normal ranges.
  • Total protein levels in the high-intensity group decreased initially but recovered by study end.
  • No significant changes in IgG, IgA, or IgM levels were observed across any groups during monthly measurements.

    • Conclusions:

    • Weekly donation of 500-600 ml plasma poses minimal risk of total protein or immunoglobulin depletion in eligible donors.
    • The frequency of IgG and IgM testing may be reduced, and IgA testing limited to initial donations.