Interrelationship between dietary lipids and calories and experimental mammary gland tumorigenesis

The purpose of this communication was to review and critique the studies designed to examine the interrelationship between dietary fat and calories in experimental rodent mammary gland tumorigenesis. The results of these studies clearly show that hyperalimentation of fat, either saturated or unsaturated, significantly stimulates this tumorigenic process. This has been demonstrated in an impressive array of carcinogen-induced, transplantable, spontaneous, and metastatic experimental rodent mammary gland tumor systems. The stimulatory effect of high levels of dietary fat appears to act primarily at the promotional stage of this tumorigenic process. Whether the mammary tumor stimulatory effect of high levels of dietary fat is a result of the metabolic activity of the fat per se or is due to an excessive energy (caloric) intake has been examined. Data obtained from the experimental studies that address this issue support the viewpoint that the mammary tumorigenic-enhancing activities of a high fat diet is, at least in part, through a caloric mechanism.