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Three cases of arthritis after BCG therapy for bladder cancer
P Goupille1, J L Poet, F Jattiot
1Department of Rheumatology, CHU, Hôpital Trousseau, Tours, France.
Clinical and Experimental Rheumatology
|March 1, 1994
Abstract:
The authors report three cases of arthritis occurring after treatment with BCG immunotherapy for bladder disease. This complication is observed in 0.5 to 1% of treated patients and affects the small joints within 1 to 5 months of the first BCG injection. The clinical outcome is favourable with non-steroidal antiinflammatory drugs. This form of arthritis may be attributable to a cross-reaction between antigenic components of cartilaginous proteoglycan and BCG, influenced by a particular HLA-DR pattern, and with the intervention of a heat shock protein.