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Cryptococcosis: involvement of more than one system
1Department of Tuberculosis and Chest Diseases, B.J. Medical College, Pune.
The Indian Journal of Chest Diseases & Allied Sciences
|October 1, 1993
Summary
A patient with pulmonary cryptococcosis developed meningitis and brain lesions. Successful treatment involved amphotericin-B and 5-flucytosine, leading to lesion resolution and reduction.
Area of Science:
- Infectious Diseases
- Neurology
- Pulmonology
Background:
- Pulmonary cryptococcosis is a fungal infection that can disseminate to the central nervous system.
- Cryptococcal meningitis and brain cryptococcomas are serious complications requiring prompt diagnosis and treatment.
Observation:
- A 37-year-old female presented with cough and fever, indicative of pulmonary cryptococcosis.
- Within a week, she developed cryptococcal meningitis, followed by brain cryptococcomas five months later.
Findings:
- The patient received two courses of amphotericin-B, with initial co-administration of 5-flucytosine.
- Pulmonary lesions resolved completely, and brain cryptococcomas showed a reduction in number and size.
Implications:
- This case highlights the potential for disseminated cryptococcosis from pulmonary origins.
- Effective treatment regimens combining amphotericin-B and 5-flucytosine can manage severe neurological complications.
- Long-term monitoring is crucial for patients with cryptococcal brain lesions.