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Endodermal sinus tumor: report of 12 cases

B R Agarwal1, M Patel, B N Shah

  • 1Department of Pediatric Hematology and Oncology, B.J. Wadia Hospital for Children, Parel, Bombay.

Indian Pediatrics
|November 1, 1993
PubMed
Summary

Endodermal sinus tumors, often diagnosed in young children, showed significant response to surgery and chemotherapy. The BVP regimen achieved clinical remission in all patients after the first treatment cycle.

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Area of Science:

  • Pediatric Oncology
  • Surgical Pathology

Background:

  • Endodermal sinus tumors are rare germ cell tumors predominantly affecting children.
  • These tumors can arise in various primary sites, including sacrococcygeal, vaginal, and retroperitoneal locations.

Purpose of the Study:

  • To review cases of endodermal sinus tumors to understand patient demographics, primary sites, diagnostic methods, and treatment outcomes.
  • To evaluate the efficacy of surgery and the BVP chemotherapy regimen in achieving remission.

Main Methods:

  • Retrospective review of twelve endodermal sinus tumor cases.
  • Diagnosis confirmed by histopathological examination and elevated serum alfa feto protein levels.
  • Treatment involved surgery and the BVP (Bleomycin, Vincristine, Cisplatin) chemotherapy regimen.

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Main Results:

  • The study included 10 females and 2 males with a median age of 3 years.
  • Common primary sites included sacrococcygeal (4), vaginal (3), and retroperitoneal (2).
  • All patients receiving the BVP regimen achieved clinical remission after the first treatment cycle, irrespective of disease stage or follow-up status.

Conclusions:

  • Endodermal sinus tumors in pediatric patients demonstrate a high response rate to combined surgical and BVP chemotherapy treatment.
  • The BVP regimen is highly effective in inducing rapid clinical remission for endodermal sinus tumors.