Related Experiment Videos
Proliferative actinic keratosis
L H Goldberg1, A K Joseph, J A Tschen
1Department of Dermatology, Baylor College of Medicine, Houston, Texas 77030.
Background:
Solar/actinic keratoses (AKS) are premalignant lesions, usually less than 1 cm in diameter, that appear on chronically sun-damaged skin.
Methods:
We describe four patients with a form of AK that enlarged and recurred despite standard treatment. Histologic examination revealed a single and multilayered sheet of anaplastic cells along the undersurface of the epidermis extending down hair follicles and present over a large area.
Results:
Three of the patients developed either a squamous cell carcinoma (SCC) or basal cell carcinoma (BCC) within the area encompassed by the AK.
Conclusions:
These cases represent an insidious, proliferative form of AK with an increased tendency to develop into skin cancer.
Insights
This study identifies an aggressive form of actinic keratosis (AK) that grows and recurs despite treatment. This insidious skin condition has a higher risk of progressing to squamous cell carcinoma or basal cell carcinoma.
Area of Science:
- Dermatology
- Oncology
Background:
- Actinic keratoses (AKs) are common premalignant skin lesions on sun-damaged skin.
- Standard treatments are often effective for typical AKs.