Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Optimizing brachytherapy for locally advanced cervical cancer

C G Niël1, P C Koper, A G Visser

  • 1Dr. Daniel den Hoed Cancer Center, Department of Radiation Oncology, Rotterdam, The Netherlands.

International Journal of Radiation Oncology, Biology, Physics
|July 1, 1994
PubMed
Summary

Adapted high dose rate brachytherapy effectively treats advanced cervical cancer. This technique ensures accurate irradiation of the vaginal wall and parametrial tumors using a single applicator.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Host Evolutionary History Drives Prokaryotic Diversity in the Globally Distributed Sponge Family Petrosiidae.

Molecular ecology·2025
Same author

Comparison of Cryopreservation Techniques for Cells of the Marine Sponge Dysidea etheria.

Cryo letters·2019
Same author

Temoporfin mediated photodynamic therapy in patients with local persistent and recurrent nasopharyngeal carcinoma after curative radiotherapy: a feasibility study.

Photodiagnosis and photodynamic therapy·2012
Same author

The clinical feasibility of deep hyperthermia treatment in the head and neck: new challenges for positioning and temperature measurement.

Physics in medicine and biology·2010
Same author

Stereotactic body radiation therapy for colorectal liver metastases.

The British journal of surgery·2010
Same author

Winner of the "New Investigator Award" at the European Society of Hyperthermia Oncology Meeting 2007. The HYPERcollar: a novel applicator for hyperthermia in the head and neck.

International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·2007

Area of Science:

  • Oncology
  • Radiation Oncology
  • Medical Physics

Background:

  • Cervix carcinoma extending to the vaginal wall and parametria presents a challenge for standard brachytherapy.
  • Existing high dose rate (HDR) brachytherapy applicators may not adequately cover the entire tumor volume in such cases.

Purpose of the Study:

  • To adapt an existing HDR brachytherapy applicator to achieve adequate irradiation of the uterus, parametria, and vaginal wall in patients with advanced cervix carcinoma.
  • To evaluate the dosimetric accuracy and tumor coverage of the adapted applicator.

Main Methods:

  • Modification of a standard HDR brachytherapy applicator (two ovoids and one intrauterine tube).
  • Utilized the Nucletron Planning System optimization program to achieve desired isodose distributions.

Related Experiment Videos

  • Delivered a specified dose of 8.5 Gy at point A and 5 mm vaginal wall depth per fraction using a single applicator.

    • Main Results:

    • The adapted HDR brachytherapy applicator provided more adequate irradiation of the vaginal and parametrial tumor components.
    • Achieved higher dosimetric accuracy compared to standard techniques.
    • Fractionated HDR brachytherapy with the adapted applicator enabled comprehensive tumor coverage.

    Conclusions:

    • Adapting existing HDR brachytherapy applicators is feasible and effective for treating advanced cervix carcinoma.
    • This modified approach enhances treatment precision and improves tumor control for challenging cases.
    • Fractionated HDR brachytherapy with applicator adaptation offers a viable solution for comprehensive tumor irradiation.