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Synthesis and anticandidal activities of optimized analogs of antibiotic Sch 37137
R Andruszkiewicz1, T Zieniawa, H Chmara
1Department of Pharmaceutical Technology and Biochemistry, Technical University of Gdańsk, Poland.
The Journal of Antibiotics
|June 1, 1994
Abstract:
Peptide analogues of Sch 37137 the antifungal antibiotic have been synthesized and evaluated in vitro against Candida sp. Di- and tripeptides containing methionine, leucine, norvaline, lysine, glutamic acid and N3-(trans-epoxysuccinamoyl)-L-2,3-diaminopropanoic acid, (EADP) were obtained. Peptides containing (D)-, and (L)-trans-epoxysuccinamic acid were also prepared. All of the analogues examined displayed in general higher anticandidal activity than a mixture of diastereomers of Sch 37137.