Related Experiment Videos
Keloids treated with excision followed by radiation therapy
D I Klumpar1, J C Murray, M Anscher
1Division of Dermatology, Duke University Medical Center, Durham, NC 27710.
Background:
In the treatment of keloids surgical excision followed by radiation therapy provides the highest reported control rates of 72% to 92%.
Objective:
We evaluated the effectiveness of excision followed by radiation therapy in the treatment of keloids and compared the efficacy of orthovoltage and electron beam radiation.
Methods:
One hundred twenty-six keloids were treated with radiation therapy after surgical excision. Median follow-up period was 12 years. Recurrence rate, side effects, and effectiveness of therapy were assessed. Data were analyzed with multivariate analysis for significant objective and subjective factors.
Results:
Higher posttreatment recurrence rates were noted with keloids forming at infected sites and in patients with a family history. No increased likelihood of recurrence was noted with respect to patient age, sex, or ethnicity; keloid size or location; individual keloid history; or prior therapy or radiation type used.
Conclusion:
Excision followed by radiation therapy is a useful and effective method of keloid eradication, particularly in cases in which lesions are disfiguring or refractory. Electron beam radiation offers no advantage over orthovoltage as a treatment.