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Keloids treated with excision followed by radiation therapy
D I Klumpar1, J C Murray, M Anscher
1Division of Dermatology, Duke University Medical Center, Durham, NC 27710.
Journal of the American Academy of Dermatology
|August 1, 1994
Summary
Surgical excision followed by radiation therapy is effective for keloid eradication. Recurrence is linked to infected sites and family history, not radiation type or patient factors.
Area of Science:
- Dermatology
- Radiation Oncology
Background:
- Keloid treatment often involves surgical excision combined with radiation therapy.
- This multimodal approach yields high reported keloid control rates, ranging from 72% to 92%.
Purpose of the Study:
- To assess the effectiveness of surgical excision followed by radiation therapy for keloid treatment.
- To compare the efficacy of orthovoltage versus electron beam radiation therapy in keloid management.
Main Methods:
- A study involving 126 keloids treated with post-excision radiation therapy.
- A median follow-up period of 12 years was maintained.
- Recurrence rates, side effects, and overall effectiveness were evaluated using multivariate analysis.
Main Results:
- Keloid recurrence was higher in cases originating from infected sites and in patients with a family history of keloids.
- No significant difference in recurrence rates was observed based on patient demographics, keloid characteristics, or radiation therapy type.
Conclusions:
- Surgical excision plus radiation therapy is a valuable and effective strategy for eradicating keloids, especially disfiguring or resistant ones.
- Electron beam radiation does not provide a significant therapeutic advantage over orthovoltage radiation for keloid treatment.