Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cell membrane, a target for PUVA therapy

Z Zarebska1

  • 1Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw.

Journal of Photochemistry and Photobiology. B, Biology
|May 1, 1994
PubMed
Summary

Psoralen compounds react with cell membrane phospholipids, altering cell functions and potentially triggering physiological responses. This research explores psoralen photobiology, relevant to psoralen plus UVA radiation (PUVA) photochemotherapy.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

PUVA (psoralen + UVA) photochemotherapy: processes triggered in the cells.

Farmaco (Societa chimica italiana : 1989)·2001
Same author

Spectroscopic detection of photoproducts in lecithin model system after 8-methoxypsoralen plus UV-A treatment.

Journal of photochemistry and photobiology. B, Biology·2000
Same author

Photoreactions of psoralens with lecithins.

Journal of photochemistry and photobiology. B, Biology·1998
Same author

Psoralen photosensitization: damages to nucleic acid and membrane lipid components.

Acta biochimica Polonica·1996
Same author

Two subpopulations of patients with early and late onset of psoriasis differ regarding alpha 1-proteinase inhibitor activity.

Acta dermato-venereologica. Supplementum·1989
Same author

[Disorders of the proteinase system -- proteinase inhibition in the pathogenesis of skin diseases].

Przeglad dermatologiczny·1989

Area of Science:

  • Photochemistry
  • Cell Biology
  • Biophysics

Background:

  • Cell membrane photochemical reactions, including sensitized photo-oxidation and psoralen photoaddition to lipids, are critical.
  • Phospholipid dynamics within cell membranes, exemplified by erythrocyte lipid organization, are fundamental to membrane structure and function.

Purpose of the Study:

  • To review photochemical reactions in cell membranes.
  • To describe phospholipid dynamics in membrane structure.
  • To illustrate the feasibility of studying psoralen photobiology with phospholipids, highlighting their role in triggering physiological responses relevant to PUVA photochemotherapy.

Main Methods:

  • Review of photochemical reactions in cell membranes.
  • Description of phospholipid dynamics based on erythrocyte lipid organization.
  • Presentation of evidence for cell membrane function alterations under psoralen plus UVA radiation (PUVA) treatment.

Main Results:

  • Evidence indicates alterations in cell membrane functions following PUVA treatment across various mammalian cells.
  • Cell receptor dysfunctions have been demonstrated under PUVA treatment in multiple biological investigations.
  • Psoralen reactions with phospholipids are proposed as a key mechanism initiating subsequent physiological responses.

Conclusions:

  • Psoralen photobiology can be effectively studied using phospholipids.
  • Psoralen-phospholipid interactions are significant in understanding PUVA-induced cellular effects.
  • These findings have implications for psoralen plus UVA radiation (PUVA) photochemotherapy efficacy and mechanisms.

Related Experiment Videos