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Microorganisms and psoriasis
E W Rosenberg1, P W Noah, R B Skinner
1Department of Dermatology, University of Tennessee College of Medicine, Memphis 38163.
Journal of the National Medical Association
|April 1, 1994
Summary
Psoriasis may stem from microbial triggers activating the complement system. Investigating and treating these specific microorganisms with antibiotics shows promising results, comparable to standard psoriasis therapies.
Area of Science:
- Dermatology
- Immunology
- Microbiology
Background:
- Psoriasis is hypothesized to be an inflammatory condition triggered by microbial stimuli.
- These stimuli may primarily activate the alternative complement pathway, contributing to psoriasis pathogenesis.
Purpose of the Study:
- To investigate the role of microorganisms in psoriasis.
- To evaluate the efficacy of antimicrobial treatment for psoriasis based on identified microbes.
Main Methods:
- A dedicated
- Problem Psoriasis Clinic
- was established.
- Patients underwent detailed questioning, physical examinations, and microbiologic laboratory investigations.
- Treatment involved antibiotics targeting identified microorganisms.
Main Results:
- Commonly identified microorganisms in psoriasis patients were listed.
- Specific treatments for each identified microorganism were described.
- The outcomes of this antimicrobial approach were favorable compared to conventional psoriasis treatments.
Conclusions:
- Microbiologic investigation and a trial of antimicrobial therapy are recommended before employing more intensive treatments for psoriasis.
- This approach offers a viable alternative for managing psoriasis, particularly when standard treatments are insufficient.