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Reference values of motor unit action potentials obtained with multi-MUAP analysis

C Bischoff1, E Stålberg, B Falck

  • 1Department of Clinical Neurophysiology, University Hospital, Uppsala, Sweden.

Muscle & Nerve
|August 1, 1994
PubMed
Summary

This study establishes reference values for motor unit action potentials (MUAPs) in healthy adults, finding no significant age or gender effects. The multi-MUAP analysis technique proved reliable for extracting MUAP data.

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Area of Science:

  • Neurology
  • Electromyography
  • Motor Unit Physiology

Background:

  • Establishing normative data for motor unit action potentials (MUAPs) is crucial for diagnosing neuromuscular disorders.
  • Previous studies have limitations in data acquisition and analysis, necessitating updated reference values.

Purpose of the Study:

  • To collect reference values for MUAPs in five key muscles of healthy individuals across a wide age range.
  • To assess the influence of age, gender, and height on MUAP parameters.
  • To evaluate the reliability and variability of a novel multi-MUAP analysis technique.

Main Methods:

  • Recorded MUAPs from 105 healthy subjects (15-86 years) using concentric needle electrodes.
  • Employed a decomposition method termed multi-MUAP analysis to identify and extract individual MUAPs and analyze firing patterns.

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  • Measured parameters including duration, amplitude, area, and number of phases.

    • Main Results:

    • No significant changes in MUAP parameters (duration, amplitude, area, etc.) were observed with increasing age, gender, or height.
    • Higher amplitudes and shorter durations were noted compared to prior studies, potentially due to higher contraction levels enabled by the decomposition technique.
    • The multi-MUAP analysis demonstrated good measurement reliability and low inter-examiner variability.

    Conclusions:

    • The study provides robust reference values for MUAPs in deltoid, biceps, first dorsal interosseous, vastus lateralis, and anterior tibialis muscles.
    • The multi-MUAP analysis is a reliable and valid method for quantitative electromyography, suitable for clinical and research applications.
    • Age, gender, and height are not significant confounding factors for MUAP parameters in healthy adults when using advanced decomposition techniques.