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Mortality in gerbils with repetitive ischemia: CGSGS-19755/hypothermia therapy
S McCrea1, A Shuaib, T Wishart
1Department of Psychology, Faculty of Medicine, University of Saskatchewan, Saskatoon, Canada.
Neuroscience Letters
|March 28, 1994
Abstract:
Repetitive ischemia causes more severe damage than a single insult of comparable duration. Gerbils were followed for 1 month postrepetitive ischemia and 100% mortality was demonstrated in the unprotected ischemia group by 12 days postischemia. Significant protection against mortality due to repetitive ischemia was offered by both CGS-19755 and combination CGS-19755-hypothermia treatments. Current practices of sacrificing repetitive ischemia subjects shortly postischemia may lead to an underestimation of the effects of ischemia and/or an overestimation of the protective effects of experimental treatments.