Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Retinblastoma: a modification in radiation therapy technique

D R Weiss, J R Cassady, R Petersen

    Radiology
    |March 1, 1975
    PubMed
    Summary

    This study introduces a novel radiation therapy technique for retinoblastoma to prevent recurrent tumors. The new method aims to deliver a more uniform radiation dose to the entire retina, reducing marginal recurrences and protecting sensitive eye structures.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Acyl-CoA Binding Protein in White and Brown Adipose Tissue Is Dispensable for Systemic Energy Metabolism in Mice.

    Acta physiologica (Oxford, England)·2026
    Same author

    Analysis of Google users' interests in information about pacifiers: an ecological digital study.

    European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry·2024
    Same author

    A computational model of neurodegeneration in Alzheimer's disease.

    Nature communications·2022
    Same author

    The Institute on Methods and Protocols for Advancement of Clinical Trials in ADRD (IMPACT-AD): A Novel Clinical Trials Training Program.

    The journal of prevention of Alzheimer's disease·2021
    Same author

    EU./U.S. CTAD Task Force on Alzheimer's Trial Populations.

    The journal of prevention of Alzheimer's disease·2017
    Same author

    Registries and Cohorts to Accelerate Early Phase Alzheimer's Trials. A Report from the E.U./U.S. Clinical Trials in Alzheimer's Disease Task Force.

    The journal of prevention of Alzheimer's disease·2017

    Area of Science:

    • Ophthalmology
    • Radiation Oncology
    • Pediatric Oncology

    Background:

    • Single lateral radiation fields for retinoblastoma can lead to dose heterogeneity.
    • Marginal recurrences in the anterior retina are common after conventional treatment.
    • The entire retinal surface is considered at risk for retinoblastoma recurrence.

    Purpose of the Study:

    • To develop a radiation technique for treating the entire retinal surface in retinoblastoma.
    • To protect the lens and anterior chamber from excessive radiation dose.
    • To reduce the incidence of marginal and anterior retinal recurrences.

    Main Methods:

    • A modified radiation technique using two fields: a conventional lateral field and a second anterior field.
    • The anterior field incorporates a pendulum-shaped divergent lens block to shield the lens and anterior chamber.
    • The lens block's shadow covers a 10 mm diameter at the corneal surface; fields are weighted 1:4.5 (anterior:lateral).

    Main Results:

    • The described technique aims to provide a more homogeneous dose distribution across the entire retinal surface.
    • The specialized lens block effectively shields the lens and anterior chamber.
    • This approach is designed to mitigate dose heterogeneity responsible for marginal recurrences.

    Conclusions:

    • This innovative radiation therapy approach offers a potential solution for treating retinoblastoma.
    • It aims to improve treatment efficacy by covering the entire retina while preserving ocular structures.
    • Further studies are warranted to evaluate the long-term outcomes and efficacy of this technique.

    Related Experiment Videos