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Evidence that cell toxicity may contribute to the genotoxic response
H S Rosenkranz1, Y P Zhang, G Klopman
1Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pennsylvania 15261.
Regulatory Toxicology and Pharmacology : RTP
|April 1, 1994
Abstract:
Comparisons of the structural determinants associated with genotoxic effects with those associated with cell or systemic toxicity indicate extensive overlaps. These findings can be taken to indicate that toxicity may contribute to genotoxicity.