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Related Experiment Videos

Shear-induced platelet aggregation in cerebral ischemia

S Uchiyama1, M Yamazaki, S Maruyama

  • 1Department of Neurology, Tokyo Women's Medical College, Japan.

Stroke
|August 1, 1994
PubMed
Summary

Shear-induced platelet aggregation is elevated in certain stroke types and linked to larger von Willebrand factor multimers. Ticlopidine effectively reduces this aggregation, unlike low-dose aspirin, offering insights into thrombosis treatment.

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Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Neurology

Background:

  • Shear-induced platelet aggregation is implicated in arterial thrombosis.
  • Understanding this mechanism is crucial for managing cerebrovascular diseases.

Purpose of the Study:

  • To measure shear-induced platelet aggregation in patients with cerebral ischemia.
  • To correlate findings with hemostatic parameters and assess antiplatelet agent efficacy.

Main Methods:

  • Utilized a cone-plate streaming chamber to induce high shear stress (108 dynes/cm2) in platelet-rich plasma.
  • Analyzed 75 patients with cerebral ischemia and 26 controls.
  • Assessed correlations with platelet count, fibrinogen, beta-thromboglobulin, and von Willebrand factor (vWF) multimers. Evaluated effects of aspirin and ticlopidine.

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Main Results:

  • Increased shear-induced platelet aggregation was observed in atherothrombotic stroke and transient ischemic attack patients.
  • No significant correlation found with platelet count, fibrinogen, or beta-thromboglobulin.
  • Aggregation correlated with larger von Willebrand factor multimers; ticlopidine inhibited it, while low-dose aspirin did not.

Conclusions:

  • Shear-induced platelet aggregation is heightened in atherothrombotic stroke and TIAs.
  • This aggregation is associated with increased larger vWF multimers.
  • Ticlopidine effectively reduces shear-induced platelet aggregation, but low-dose aspirin does not.