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Updated: Oct 8, 2026

Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells
Published on: May 4, 2018
[Effects of cadmium on vitamin D function involved in the regulation of phosphorus-calcium metabolism]
Abstract:
The role of vitamin D in regulation of phosphoric-calcium metabolism was evaluated in conditions of experimental cadmium intoxication induced by daily dietetic intake (100 micrograms/kg for 8 months) of cadmium in parallel with intake of calcium in diverse amounts. Daily requirements in vitamin D were provided in different groups of animals either with ergocalciferol (D2) or 24,25-dihydroxycholecalciferol (0.25 microgram per animal). The results of the trial suggested that despite regular supply of ergocalciferol, renal damage induced by cadmium intoxication was associated with phosphoric-calcium metabolic derangement which is likely to result from defects in renal synthesis of active vitamin D form. This was confirmed by the fact that the change of ergocalciferol for 24,25-dihydroxycholecalciferol did not produce any noticeable shifts in the phosphoric-calcium metabolism.
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