[Effect of diuretics on renal sodium excretion of different ages (I)]

Ninety normal students including 30 cases in senior high, 30 cases in junior high and 30 cases in elementary schools were the subjects for diuretic test. Thirty cases in each age group were divided into three subgroups. Students in each subgroup were given one of three oral diuretic drugs (acetazolamide 10 mg/kg, furosemide 2 mg/kg, hydrochlorothiazide 2 mg/kg) for three consecutive days. Although there was an increased urinary sodium excretion among the three different age groups during the period of oral hydrochlorothiazide, it showed no significant difference among the three age groups (P > 0.05). There was more increased urinary sodium excretion for students of senior high school during the period of oral furosemide and acetazolamide than for students of junior high school and of elementary school. The largest, successive natriuretic action was observed in students of senior high school during the period of oral furosemide. It is suggested that there is more effective natriuretic action for students of senior high school during the period of oral acetazolamide and furosemide than for students of junior high and of elementary school.