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Cogwheel rigidity related to lithium maintenance

B Shopsin, S Gershon

    The American Journal of Psychiatry
    |May 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Long-term lithium carbonate therapy for affective illness may cause cogwheel rigidity, a neurological symptom. This symptom appears to worsen with longer treatment duration and is not alleviated by benztropine.

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    Area of Science:

    • Neurology
    • Psychiatry
    • Pharmacology

    Background:

    • Lithium carbonate is a common maintenance therapy for recurrent affective disorders.
    • Neurological side effects of lithium can impact patient quality of life.

    Purpose of the Study:

    • To investigate the prevalence and characteristics of cogwheel rigidity in patients on long-term lithium therapy.
    • To explore the correlation between lithium treatment duration and cogwheel rigidity severity.

    Main Methods:

    • Neurological examinations were performed on 27 outpatients undergoing lithium carbonate maintenance therapy.
    • The severity of cogwheel rigidity was assessed.
    • The effect of intravenous benztropine administration on cogwheel rigidity was evaluated.

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    Main Results:

    • Most patients receiving lithium for over 8 months exhibited cogwheel rigidity.
    • A positive correlation was observed between the duration of lithium maintenance and the severity of cogwheeling.
    • Benztropine did not significantly reduce or eliminate cogwheel rigidity.

    Conclusions:

    • Cogwheel rigidity is a common neurological finding in patients on long-term lithium carbonate therapy.
    • The duration of lithium treatment is associated with increased severity of cogwheel rigidity.
    • Benztropine is ineffective in managing lithium-induced cogwheel rigidity.