[Characteristics of antilysozyme activity of Staphylococcus aureus in various types of experimental infection course]

The connection between the level of Staphylococcus Aureus anti-lysozyme activity (ALA) and the character of the experimental infection course has been revealed. The subsiding type of infection was developed by infecting by clones with the low ALA and at the same time there was a shift in the structure of population at the final stage of infectious process to the reduction of its heterogeneity in respect of ALA and the preservation of the colonies only with the zero and low ALA. The protracted form of infection was provoked by the clone with the high ALA and the dynamics of microbial dissemination had rhythmical nature and a high heterogeneity in respect of ALA in the structure of population of staphylococcus was preserved and the selection of colonies with the high ALA was observed. ALA of staphylococcus is an important link of pathogenesis of persistence as it determines the duration and dynamics of the survival of the pathogen in the organism.