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Updated: Aug 16, 2026

Accurate and Simple Measurement of the Pro-inflammatory Cytokine IL-1β using a Whole Blood Stimulation Assay
06:29

Accurate and Simple Measurement of the Pro-inflammatory Cytokine IL-1β using a Whole Blood Stimulation Assay

Published on: March 1, 2011

[Interconnection of interleukin-1 and glucocorticoid hormones in regulating the immune response]

A S Simbirtsev, A Iu Kotov, N V Pigareva

    Biulleten' Eksperimental'Noi Biologii I Meditsiny
    |February 1, 1993
    PubMed

    IL-1 and hydrocortisone have an opposite and competitive effect on the lymphocyte proliferation in cell culture. In mice recombinant human IL-1 beta dose-dependently induces high level serum corticosterone. Injection of IL-1 beta or hydrocortisone led to a similar alterations in the thymus: reduction of cellularity and decrease in spontaneous thymocyte proliferation. On the other hand in the same doses IL-1 beta stimulates spleen cell proliferation. IL-2 production and enhances serum antibody titres and the number of antibody producing cells in spleen of mice immunized with T-dependent antigen.

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