[Role of the striatal serotoninergic apparatus in Parkinsonian syndrome]

Injected into the rat caudate nuclei (CN) serotonin promotes the generator of pathologically enhanced excitation (GPEE) in CN and parkinsonian symptoms, induced by MPP+ injection into substantia nigra. Serotonin antibody injected in CN decreases the GPEE activity and partly suppresses the parkinsonian symptoms. The role of serotoninergic system in parkinsonism is discussed.