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Different mass spectrometric approaches in the identification of endogenous methylated purine bases in urine extracts
B Porcelli1, R Pagani, L Lorenzini
1Istituto di Biochimica ed Enzimologia, Siena, Italy.
Rapid Communications in Mass Spectrometry : RCM
|June 1, 1994
Abstract:
A preliminary identification of endogenous and exogenous methylated purine bases in urinary extracts of healthy and tumor-bearing subjects has been performed using high performance liquid chromatography, and tandem mass spectrometry (MS/MS). MS/MS gave particularly fast and sensitive analyses, allowing the simultaneous and rapid determination of 26 different urinary methylated purines. Both sets of data confirm that tumor-bearing patients show changed levels of methylated purine bases.