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Obsessive-compulsive disorders in Pick's disease

J M Tonkonogy¹, T W Smith, P J Barreira

¹Department of Psychiatry, University of Massachusetts Medical Center, Worcester 01655.

The Journal of Neuropsychiatry and Clinical Neurosciences

|January 1, 1994

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This study details a patient with obsessive-compulsive disorder (OCD) who later died from Pick's disease. Neuropathology revealed significant caudate nucleus atrophy, suggesting a link between this brain region and OCD development.

Area of Science:

Neuroscience
Neuropathology
Neuroimaging

Background:

Presents a follow-up on a patient initially diagnosed with obsessive-compulsive disorder (OCD).
Details the progressive worsening of the patient's condition, culminating in death five years after disease onset.

Observation:

Neuropathological examination confirmed Pick's disease, characterized by frontotemporal atrophy.
Striking atrophy, neuronal loss, and gliosis were observed in the caudate nuclei, putamen, and globus pallidus.

Findings:

Early-stage neuroimaging identified isolated caudate nucleus atrophy in the patient.
OCD was the primary clinical manifestation during the early stages of the disease.

Implications:

Related Experiment Videos

Discusses the potential role of caudate nucleus atrophy in the pathogenesis of obsessive-compulsive disorder (OCD).

Highlights the significance of neuroimaging findings in diagnosing rare neurological conditions presenting with psychiatric symptoms.