Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Statistical methods in neuroimaging with particular application to emission tomography

J H McColl1, A P Holmes, I Ford

  • 1Department of Statistics, University of Glasgow, UK.

Statistical Methods in Medical Research
|January 1, 1994
PubMed
Summary

This review covers statistical methods for Positron Emission Tomography (PET) and Single-Photon Emission Computed Tomography (SPECT) neuroimaging. It focuses on image reconstruction, kinetic modeling, region-of-interest analysis, and voxel-level inference, especially for serial scans.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Familial atrial fibrillation mutation M1875T-SCN5A increases early sodium current and dampens the effect of flecainide.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology·2022
Same author

Resting heart rate and incident atrial fibrillation: A stratified Mendelian randomization in the AFGen consortium.

PloS one·2022
Same author

Polypharmacy, functional outcome and treatment effect of intravenous alteplase for acute ischaemic stroke.

European journal of neurology·2020
Same author

Cost burden of Clostridioides difficile infection to the health service: A retrospective cohort study in Scotland.

The Journal of hospital infection·2020
Same author

The kidney, subclinical thyroid disease and cardiovascular outcomes in older patients.

Endocrine connections·2019
Same author

Genome-wide meta-analysis of variant-by-diuretic interactions as modulators of lipid traits in persons of European and African ancestry.

The pharmacogenomics journal·2019

Area of Science:

  • Neuroimaging
  • Statistical Analysis
  • Medical Physics

Background:

  • Positron Emission Tomography (PET) and Single-Photon Emission Computed Tomography (SPECT) are crucial neuroimaging modalities.
  • Advanced statistical methods are essential for extracting meaningful information from complex neuroimaging data.
  • Current applications span image reconstruction to detailed data analysis.

Purpose of the Study:

  • To provide a comprehensive review of statistical methodologies in PET and SPECT neuroimaging.
  • To highlight key areas where statistical approaches are applied.
  • To identify future directions for statistical research in the field.

Main Methods:

  • Review of statistical techniques in four core neuroimaging areas: image reconstruction, tracer-kinetic modeling, region-of-interest (ROI) analysis, and voxel-level inference.

Related Experiment Videos

  • Specific emphasis on statistical analysis of serial scan data.
  • Synthesis of current practices and identification of research gaps.

    • Main Results:

    • Statistical methods are integral to image reconstruction in PET and SPECT.
    • Tracer-kinetic modeling relies heavily on statistical inference for understanding physiological processes.
    • Region-of-interest and voxel-level analyses, particularly with serial data, offer insights into dynamic brain changes.

    Conclusions:

    • Statistical methods are fundamental to advancing PET and SPECT neuroimaging.
    • Further research is needed in areas like advanced voxel-level analysis and serial data interpretation.
    • The review identifies critical topics for future statistical investigation in neuroimaging.