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The role of apolipoprotein E in the nervous system
K H Weisgraber1, A D Roses, W J Strittmatter
1Gladstone Institute of Cardiovascular Disease, San Francisco, California.
Current Opinion in Lipidology
|April 1, 1994
Abstract:
Human apolipoprotein (apo)E, an important component of plasma lipoprotein metabolism, was recently linked to Alzheimer's disease. Of the three common apoE alleles, epsilon 4 has emerged as a major risk factor. This review summarizes the data leading to this conclusion and discusses possible mechanisms for apoE involvement based on recent biochemical studies.