Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ischaemia-reperfusion injury

P A Grace1

  • 1Department of Surgery, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.

The British Journal of Surgery
|May 1, 1994
PubMed
Summary

Ischaemia-reperfusion injury causes tissue damage during surgery. This review explores its pathology, free radical mechanisms, and protective strategies to limit injury.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparing the endothelialisation of extracellular matrix bioscaffolds with coated synthetic vascular graft materials.

International journal of surgery (London, England)·2015
Same author

A MultiCenter Pilot Randomized Controlled Trial of Remote Ischemic Preconditioning in Major Vascular Surgery.

Vascular and endovascular surgery·2015
Same author

Remote preconditioning and major clinical complications following adult cardiovascular surgery: systematic review and meta-analysis.

International journal of cardiology·2014
Same author

Assessing the quality of online information for patients with carotid disease.

International journal of surgery (London, England)·2014
Same author

The impact of regional reconfiguration on the management of appendicitis.

Irish journal of medical science·2013
Same author

In a time of cholera.

Irish journal of medical science·2013

Area of Science:

  • Biomedical Science
  • Pathology
  • Surgical Research

Background:

  • Ischaemia-reperfusion injury is a significant complication in surgery.
  • It leads to local and remote tissue damage, potentially causing death.

Purpose of the Study:

  • To review the pathology of ischaemia-reperfusion injury.
  • To discuss mechanisms of free radical production and the role of neutrophils and endothelial factors.
  • To present novel therapies for limiting this injury.

Main Methods:

  • Literature review of ischaemia-reperfusion injury.
  • Discussion of pathological processes.
  • Analysis of cellular and molecular mechanisms.
  • Overview of therapeutic interventions.

Main Results:

  • Multiple processes contribute to ischaemia-reperfusion injury.
  • Free radicals, neutrophils, and endothelial factors play key roles.
  • Various mechanisms can limit injury, with novel therapies emerging.

Conclusions:

  • Understanding the mechanisms of ischaemia-reperfusion injury is crucial.
  • Targeting specific pathways offers potential for therapeutic intervention.
  • Further research into novel therapies is warranted to improve patient outcomes.

Related Experiment Videos