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Hypercoagulable states in patients with leg ischaemia
1Department of Vascular Surgery, St George's Hospital Medical School, London, UK.
The British Journal of Surgery
|June 1, 1994
Summary
Hypercoagulable states, or blood clotting disorders, are common in patients with arterial disease. These conditions may increase the risk of revascularization failure in peripheral vascular disease patients.
Area of Science:
- Vascular Medicine
- Hematology
- Thrombosis Research
Background:
- Hypercoagulable states are linked to venous thrombosis.
- Their prevalence in arterial thrombosis is less understood.
- Peripheral vascular disease (PVD) involves arterial blockages.
Purpose of the Study:
- To determine the prevalence of hypercoagulable states in patients with arterial thrombosis.
- To investigate the association between hypercoagulability and revascularization outcomes.
- To identify specific thrombophilia abnormalities in PVD.
Main Methods:
- Thrombophilia screening was conducted on 124 patients post-lower-limb revascularization.
- 45 patients with claudication and 27 controls were also screened.
- Screening assessed protein C, protein S, antithrombin III levels, and lupus anticoagulant presence.
Main Results:
- 40% of revascularized patients showed hypercoagulation abnormalities, versus 27% of claudicants and 11% of controls (P < 0.01).
- Patients experiencing reocclusion post-revascularization were more likely to have hypercoagulability (P < 0.05).
- Lupus anticoagulant and low protein C levels were most frequent and specific to PVD patients.
Conclusions:
- Hypercoagulable states are prevalent in patients with arterial disease.
- These conditions may contribute to revascularization failure in PVD.
- Screening for thrombophilia may be beneficial in managing arterial thrombosis.
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