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Platelet activation during hand vibration

P J Kent1, G A Williams, R C Kester

  • 1Department of Vascular Surgery, St James's University Hospital, Leeds, UK.

The British Journal of Surgery
|June 1, 1994
PubMed
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Vibration exposure causes intravascular platelet aggregation. Patients with vibration white finger (VWF) or Raynaud's disease show decreased platelet sensitivity to adenosine 5'-diphosphate (ADP) aggregation.

Area of Science:

  • Hematology
  • Occupational Medicine
  • Vascular Biology

Background:

  • Vibration white finger (VWF) and Raynaud's disease are conditions linked to reduced blood flow.
  • Platelet activation and aggregation are implicated in vascular disorders.

Purpose of the Study:

  • To investigate the effects of hand vibration on platelet aggregation and sensitivity in healthy individuals and patients with VWF or Raynaud's disease.
  • To assess changes in beta-thromboglobulin levels and platelet aggregation responses before and after vibration exposure.

Main Methods:

  • Blood samples were collected from 12 controls, 16 VWF patients, and 15 Raynaud's patients.
  • Platelet aggregation, beta-thromboglobulin levels, and platelet sensitivity to adenosine 5 omino-diphosphate (ADP) and collagen were measured.

Related Experiment Videos

  • Measurements were taken before and after a 1-minute hand vibration exposure.

    • Main Results:

    • Beta-thromboglobulin levels significantly increased in controls and VWF patients post-vibration.
    • Vibration did not affect circulating platelet aggregate ratio in any group.
    • Platelets from VWF and Raynaud's patients showed reduced sensitivity to low-dose ADP compared to controls.
    • A significant change in the lag phase of aggregation response to vibration was observed in controls at specific ADP concentrations.

    Conclusions:

    • Hand vibration exposure induces intravascular platelet aggregation.
    • Decreased platelet sensitivity to ADP aggregation may be a characteristic of VWF and Raynaud's disease.