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Supratentorial tumours in infants

M K Tewari1, B S Sharma, R K Mahajan

  • 1Department of Neurosurgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Child'S Nervous System : Chns : Official Journal of the International Society for Pediatric Neurosurgery
|April 1, 1994
PubMed
Summary

Supratentorial brain tumors in infants are rare but aggressive, with high mortality. Early diagnosis and improved treatments are crucial for better outcomes in these young patients.

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Area of Science:

  • Pediatric Neurosurgery
  • Pediatric Oncology
  • Neuro-oncology

Background:

  • Supratentorial brain tumors in infants (under 1 year) are uncommon, representing a small fraction of pediatric brain tumors.
  • These tumors present unique diagnostic and therapeutic challenges due to the patient's age and tumor characteristics.

Purpose of the Study:

  • To analyze the clinical presentation, histological types, and treatment outcomes of infants with supratentorial brain tumors.
  • To identify factors contributing to the high morbidity and mortality in this patient group.

Main Methods:

  • Retrospective review of 14 infants (below 1 year) with supratentorial brain tumors treated over 4 years.
  • Data collected included clinical features, tumor histology, management strategies, and survival rates.

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Main Results:

  • Common symptoms included increased head size, vomiting, and failure to thrive. Tumors were often large and histologically malignant.
  • Perioperative mortality was high at 57%, with only 30% surviving beyond 1 year.
  • Factors like delayed diagnosis, poor pre-operative condition, and tumor aggressiveness contributed to poor outcomes.

Conclusions:

  • Infantile supratentorial brain tumors are associated with dismal prognoses due to their aggressive nature and diagnostic delays.
  • Urgent diagnosis and multimodal treatment approaches are essential to improve survival rates in this vulnerable population.