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Nonsteroidal anti-inflammatory drugs. Current ophthalmic therapy
1Department of Ophthalmology, Harvard Medical School, Boston, MS.
The Journal of the Florida Medical Association
|April 1, 1994
Summary
Topical nonsteroidal anti-inflammatory drugs (NSAIDs) treat eye inflammation and related symptoms. While effective, potential side effects necessitate careful use and further research into their therapeutic roles.
Area of Science:
- Ophthalmology
- Pharmacology
Background:
- Nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently utilized for ophthalmic inflammatory conditions.
- Four topical NSAID preparations are currently available for specific ocular uses.
Purpose of the Study:
- To review the current applications of topical NSAIDs in ophthalmology.
- To discuss the mechanism of action, adverse effects, and future therapeutic potential of these agents.
Main Methods:
- Literature review of topical NSAID preparations in ophthalmic treatment.
- Analysis of NSAID mechanism, clinical applications, and safety profiles.
Main Results:
- Topical NSAIDs like flurbiprofen and suprofen are used for miosis prevention during surgery.
- Diclofenac manages post-cataract surgery inflammation, while ketorolac treats allergic conjunctivitis itching.
- Potential adverse effects include ocular stinging, photophobia, and systemic issues like gastric sensitivity and bleeding risks.
Conclusions:
- Topical NSAIDs offer valuable treatment options for various ophthalmic inflammatory diseases.
- Awareness of potential adverse effects is crucial for safe and effective patient management.
- Further investigation into NSAID mechanisms and applications may expand their future therapeutic roles in eye care.