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Identification of an intrinsic platelet function defect in Spitz dogs
M K Boudreaux1, C Crager, A R Dillon
1Department of Pathobiology, Auburn University, AL 36849-5519.
Journal of Veterinary Internal Medicine
|March 1, 1994
Summary
A novel platelet function disorder was found in two Spitz dogs, causing chronic bleeding. This defect, similar to Basset hound thrombopathy, affects platelet aggregation but not shape change.
Area of Science:
- Veterinary Hematology
- Canine Platelet Disorders
Background:
- Intrinsic platelet function defects can cause bleeding diatheses in dogs.
- Spitz dogs are a breed with potential genetic predispositions to certain conditions.
Observation:
- Two related Spitz dogs presented with chronic bleeding from mucosal surfaces.
- Affected dogs exhibited absent platelet aggregation to adenosine diphosphate (ADP), collagen, and platelet-activating factor (PAF), but normal shape change.
- Platelet aggregation to gamma thrombin was present but showed delayed onset and reduced velocity.
- Platelet serotonin release was diminished in response to collagen and PAF.
- Glycoprotein IIIa was detected on platelet surfaces; morphology was normal.
Findings:
- A distinct intrinsic platelet function defect was identified in the affected Spitz dogs.
- The defect impairs multiple pathways of platelet activation and serotonin release.
- Related, unaffected Spitz dogs showed diminished collagen-induced platelet aggregation, suggesting a familial component.
Implications:
- This finding expands the spectrum of canine inherited platelet function disorders.
- Understanding this defect aids in diagnosing and managing bleeding disorders in Spitz dogs.
- The similarity to Basset hound thrombopathy suggests a potential shared genetic or molecular pathway.