[Specificity of surface antigen and function of BAL T cells]

To elucidate the pathogenesis of sarcoidosis, we mainly investigated the surface molecules including adhesion molecules on BAL T cells and the functions of BAL T cells such cytokine production, [Ca2+] mobilization, PKC expression. Results are following. Adhesion molecules were up-regulated on BAL T cells compared with peripheral T cells, but cytokine production was decreased via TcR stimulation through [Ca2+] mobilization was occurred. PKC isozyme alpha expression was decreased compared with peripheral blood T cells.