Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Treating motor fluctuations with controlled-release levodopa preparations

W C Koller1, R Pahwa

  • 1Department of Neurology, University of Kansas Medical Center, Kansas City 66160-7314.

Neurology
|July 1, 1994
PubMed
Summary

Parkinson's disease patients experience motor fluctuations due to levodopa therapy. This review examines controlled-release levodopa preparations, Madopar HBS and Sinemet CR, to manage these motor symptoms.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The 201 Trial: a placebo-controlled randomized phase 2 study of safety and tolerance of the c-Abl kinase inhibitor risvodetinib in untreated Parkinson's disease.

Nature aging·2026
Same author

Evaluation of morning bradykinesia in Parkinson's disease in a United States cohort using continuous objective monitoring.

Clinical parkinsonism & related disorders·2022
Same author

Dopaminergic Basis of Spatial Deficits in Early Parkinson's Disease.

Cerebral cortex communications·2021
Same author

The effect of the accessory proteins, soluble CD14 and lipopolysaccharide-binding protein on Toll-like receptor 4 activity in human monocytes and adipocytes.

International journal of obesity (2005)·2016
Same author

Insulin resistance and gray matter volume in neurodegenerative disease.

Neuroscience·2014
Same author

Long-term evaluation of gait initiation in six Parkinson's disease patients with bilateral subthalamic stimulation.

Gait & posture·2011

Area of Science:

  • Neurology
  • Pharmacology
  • Movement Disorders

Background:

  • Long-term Parkinson's disease treatment with levodopa can cause motor fluctuations.
  • The
  • wearing-off
  • phenomenon is linked to plasma levodopa levels.
  • Prolonging levodopa plasma levels is a key strategy to manage motor fluctuations.

Purpose of the Study:

  • To review available data on two controlled-release levodopa preparations.
  • To assess their efficacy in managing motor fluctuations in Parkinson's disease.

Main Methods:

  • Review of scientific literature on levodopa pharmacokinetics.
  • Analysis of data on Madopar HBS and Sinemet CR.

Related Experiment Videos

Main Results:

  • Both Madopar HBS and Sinemet CR aim to prolong levodopa plasma levels.
  • These preparations are designed to mitigate motor fluctuations in Parkinson's disease patients.

Conclusions:

  • Controlled-release levodopa formulations are a principal strategy for treating motor fluctuations.
  • Further data review is essential for understanding the effectiveness of Madopar HBS and Sinemet CR.