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[The "lethal white foal" syndrome]

C Blendinger1, G Müller, H Bostedt

  • 1Ambulatorischen und Geburtshilflichen Veterinärklinik, Justus-Liebig-Universität Giessen.

Tierarztliche Praxis
|June 1, 1994
PubMed
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Lethal white foal syndrome, a congenital intestinal innervation defect, was diagnosed in a foal from overo-spotted paint horses. This condition is rare in Germany and requires further investigation.

Area of Science:

  • Veterinary Pathology
  • Equine Genetics
  • Gastrointestinal Physiology

Background:

  • Lethal white foal syndrome (LWFS) is a fatal congenital disorder in horses.
  • It is characterized by aganglionosis of the gastrointestinal tract, leading to functional obstruction.
  • LWFS is primarily associated with the Overo gene in Paint horses.

Observation:

  • A case study of a female foal born in March 1992 is presented.
  • The foal was offspring of two overo-spotted paint horses.
  • Diagnosis was confirmed through history, clinical signs, and pathological findings.

Findings:

  • The foal exhibited symptoms consistent with congenital intestinal aganglionosis.
  • Pathological examination revealed a lack of nerve ganglia in the equine gastrointestinal tract.

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  • Genetic linkage to the Overo spotting gene pattern is implicated.

    • Implications:

    • This case highlights the importance of recognizing LWFS in equine practice.
    • It underscores the need for genetic counseling for owners of overo-spotted horses.
    • Increased awareness and understanding of LWFS in Germany are crucial for early diagnosis and management.