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Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models
Published on: August 9, 2012
Laboratory variables of bladder autoaugmentation in an animal model
H W Johnson1, M K Nigro, L Stothers
1British Columbia's Children's Hospital, Vancouver, Canada.
Urology
|August 1, 1994
Summary
Vesicomyotomy and vesicomyectomy techniques for bladder augmentation showed no significant differences in radiologic, pathologic, or urodynamic outcomes. Both methods effectively increased bladder capacity in animal models.
Area of Science:
- Urology
- Surgical Innovation
- Pediatric Surgery
Background:
- Autoaugmentation, specifically vesicomyotomy, is a simplified bladder augmentation technique for hypertonic, low-capacity bladders.
- This study compares two surgical approaches: vesicomyectomy and vesicomyotomy.
Purpose of the Study:
- To evaluate and compare the functional, radiologic, and pathologic outcomes of autoaugmentation using vesicomyectomy versus vesicomyotomy.
- To assess the efficacy of these techniques in an animal model of a small-capacity hypertonic bladder.
Main Methods:
- An animal model of a small-capacity hypertonic bladder was created.
- Sixteen vesicomyotomies and 16 vesicomyectomies were performed on reduced bladders; three served as controls.
- Evaluations included radiologic, pathologic, and urodynamic studies.
Main Results:
- Radiologic studies revealed a large diverticulum with a 17.2% increase in surface area.
- Urodynamic studies showed a 43.5% increase in functional capacity and a 48.1% decrease in leak point pressure.
- Histologic examination indicated minimal muscle ingrowth at the vesicomyectomy site periphery.
Conclusions:
- No statistically significant differences were observed between vesicomyotomy and vesicomyectomy regarding radiologic, pathologic, or urodynamic outcomes.
- Both techniques appear viable for bladder augmentation in the studied model.
