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Related Experiment Videos

Prolonged bleeding time during nitric oxide inhalation in the rabbit

M Högman1, C Frostell, H Arnberg

  • 1Department of Clinical Psychology, University Hospital, Uppsala, Sweden.

Acta Physiologica Scandinavica
|May 1, 1994
PubMed
Summary

Inhaled nitric oxide (NO) significantly increases bleeding time in rabbits at concentrations of 30 parts per million (ppm) and above. This suggests NO exerts systemic effects impacting hemostasis.

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Area of Science:

  • Physiology
  • Pharmacology

Background:

  • Nitric oxide (NO) is a gas with known physiological roles.
  • Its modulatory effects on airways are under investigation.
  • An unexpected increase in bleeding tendency was observed during NO inhalation studies.

Purpose of the Study:

  • To investigate the effect of inhaled nitric oxide (NO) on bleeding time and blood rheology in rabbits.
  • To determine the dose-dependent systemic effects of NO inhalation.

Main Methods:

  • Rabbits were mechanically ventilated under neurolept anesthesia.
  • Inhalation of varying concentrations of NO (3, 30, 300 ppm) was administered.
  • Bleeding time, haematocrit, blood viscosity, erythrocyte aggregation, and deformability were measured.
  • Mean arterial pressure (MAP) was monitored during NO inhalation.

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Main Results:

  • Inhaled NO significantly increased bleeding time at 30 ppm (P < 0.001) and 300 ppm (P < 0.05).
  • No significant changes were observed in haematocrit or blood rheology parameters.
  • Mean arterial pressure decreased significantly at 300 ppm NO (P < 0.05).

Conclusions:

  • Inhaled nitric oxide (NO) at concentrations of 30 ppm and above exerts systemic effects.
  • NO inhalation can increase bleeding tendency without altering key blood rheological properties.
  • These findings highlight potential hemostatic risks associated with high-concentration NO therapy.