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Positional nystagmus in association with macroglobulinemia
The Annals of Otology, Rhinology, and Laryngology
|March 1, 1975
Summary
Waldenstrom's macroglobulinemia can cause dizziness by altering vestibular cupulae. This suggests macroglobulins may directly affect inner ear function, offering a new understanding of neuro-otologic symptoms.
Area of Science:
- Neurology
- Otolaryngology
- Hematology
Background:
- Waldenstrom's macroglobulinemia is a lymphoproliferative malignancy linked to monoclonal macroglobulinemia.
- Existing theories for cochlear and vestibular symptoms focus on vascular events like thrombosis or hemorrhage.
Purpose of the Study:
- To investigate an alternative mechanism for vestibular disturbances in Waldenstrom's macroglobulinemia.
- To explore the direct impact of macroglobulins on inner ear function.
Main Methods:
- Reviewed five patients undergoing treatment for Waldenstrom's macroglobulinemia.
- Conducted extensive neuro-otologic examinations, including electronystagmography, on three patients with a history of dizziness.
Main Results:
- Three patients reported recurrent episodes of dizziness.
- Electronystagmography results indicated potential alterations in vestibular cupulae due to macroglobulins.
- Findings suggest macroglobulins may function as gravity receptors in the altered cupulae.
Conclusions:
- Macroglobulin deposition may directly impact vestibular function in Waldenstrom's macroglobulinemia.
- This presents a novel pathophysiological mechanism for dizziness in this condition, distinct from vascular causes.