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Related Experiment Videos

Quinine-associated acute interstitial nephritis

R Pawar1, G H Jacobs, M C Smith

  • 1Department of Medicine, University Hospitals of Cleveland, OH 44106.

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
|August 1, 1994
PubMed
Summary
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Quinine can cause acute renal failure, often linked to hemolytic-uremic syndrome. This case highlights acute interstitial nephritis from quinine, successfully treated with steroid therapy.

Area of Science:

  • Nephrology
  • Toxicology
  • Pharmacology

Background:

  • Quinine is an antimalarial and antiarrhythmic drug.
  • Quinine-induced renal failure is rarely reported, often associated with hemolytic-uremic syndrome.
  • Acute interstitial nephritis is a potential adverse effect of drug ingestion.

Observation:

  • A patient developed acute renal failure following quinine ingestion.
  • The renal failure was characterized by acute interstitial nephritis, not hemolytic-uremic syndrome.
  • The patient's condition improved significantly after initiating steroid treatment.

Findings:

  • This case demonstrates a distinct presentation of quinine-induced acute renal failure.
  • Acute interstitial nephritis is a plausible mechanism for quinine-induced kidney injury.

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  • Steroid therapy can be effective in managing quinine-induced acute interstitial nephritis.

    • Implications:

    • Highlights the importance of considering drug-induced nephrotoxicity, specifically quinine.
    • Suggests an alternative mechanism (acute interstitial nephritis) for quinine-related renal dysfunction.
    • Supports the use of corticosteroids in managing such cases, potentially preventing long-term kidney damage.