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Liver resection for hepatocellular carcinoma in the elderly
K Takenaka1, M Shimada, H Higashi
1Department of Surgery, Fukuoka City Hospital, Japan.
Archives of Surgery (Chicago, Ill. : 1960)
|August 1, 1994
Summary
Hepatic resection for hepatocellular carcinoma (HCC) in elderly patients (≥70 years) showed satisfactory outcomes, comparable to younger patients. While elderly patients had higher hepatic failure rates, long-term survival was similar.
Area of Science:
- Hepatobiliary surgery
- Surgical oncology
- Geriatric medicine
Background:
- Hepatocellular carcinoma (HCC) is a significant health concern, particularly in aging populations.
- Surgical management of HCC in elderly patients requires careful consideration of risks and benefits.
Purpose of the Study:
- To evaluate the effectiveness and safety of hepatic resection for HCC in elderly patients.
- To compare outcomes of HCC resection in elderly versus younger patient cohorts.
Main Methods:
- Retrospective study comparing 39 elderly (≥70 years) and 229 younger (<70 years) patients undergoing hepatic resection for HCC.
- Analysis of preoperative clinical features, postoperative morbidity, survival rates, and pathological characteristics.
- Data collected from municipal and university hospitals in Japan between April 1985 and March 1993.
Main Results:
- Elderly patients had a higher incidence of postoperative hepatic failure (10% vs. 2%, P = .018).
- Operative death rates, other postoperative complications, long-term survival (5-year: 75.9% vs. 51.6%), and disease-free survival (5-year: 30.4% vs. 31.0%) were similar between groups.
- Pathological features of HCC were identical in both elderly and younger patients.
Conclusions:
- Hepatic resection for HCC in elderly patients yields satisfactory outcomes.
- Despite increased hepatic failure risk, elderly patients can achieve comparable long-term survival to younger counterparts after HCC resection.