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Published on: January 27, 2019
Spontaneous Clostridium septicum myonecrosis in congenital neutropaenia
G Keogh1, I Unsworth, M Vowels
1Department of Surgery, Prince of Wales Children's Hospital, Randwick, New South Wales, Australia.
Abstract:
Spontaneous Clostridium septicum myonecrosis is an uncommon disorder that has been described in association with malignancy, immunosuppression and neutropaenia. Typical clostridial myonecrosis develops without a visible portal of entry and mortality is high. The pathogenesis is not completely understood but the clostridia may gain access to the circulation via areas of ileo-caecal ulceration secondary to enterocolitis, antibiotics or neoplasms. A 5 year old boy with congenital neutropaenia presented with spontaneous Clostridium septicum myonecrosis in the thigh. Limb salvage was achieved using antibiotics, hyberbaric oxygenation and selective debridement. The portal of entry may have been the gastrointestinal tract as colonic ulceration may occur in neutropaenia, and pre-morbid clindamycin administration may have encouraged overgrowth of colonic clostridia.
Insights
Spontaneous Clostridium septicum myonecrosis is a rare condition often linked to weakened immunity. This case highlights successful limb salvage in a child with congenital neutropaenia using a multimodal treatment approach.
Area of Science:
- Infectious Diseases
- Pediatric Surgery
- Hematology
Background:
- Spontaneous Clostridium septicum myonecrosis is a rare and severe condition.
- It is often associated with malignancy, immunosuppression, and neutropaenia.
- The exact pathogenesis remains unclear, but gastrointestinal tract translocation is a suspected route.
