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Cytotoxic activity of some gold(III) complexes
F Cossu1, Z Matovic, D Radanovic
1Istituto di Radiologia, Università di Cagliari, Ospedale Civile, Italy.
Farmaco (Societa Chimica Italiana : 1989)
|April 1, 1994
Abstract:
The [Au(N-MeIm)Cl3], [Au(2-MeBO)Cl3] and [Au(2,5-diMeBO)Cl3] complexes (where N-MeIm = N-methylimidazole, 2-MeBO = 2-methylbenzoxazole and 2,5-diMeBO = 2,5-dimethylbenzoxazole), had been previously prepared and characterized by the Author. These compounds, when tested in vitro against murine leukemia cell lines L1210, human ovarian carcinoma A2780 and their sublines L1210/CDDP and A2780/CDDP resistant to cisplatin, in comparison with cisplatin and carboplatin, showed an interesting cytotoxicity, extended to resistant sublines.