Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bacterial genomics

S T Cole1, I Saint Girons

  • 1Unité de Génétique Moléculaire Bactérienne, Institut Pasteur, Paris, France.

FEMS Microbiology Reviews
|June 1, 1994
PubMed
Summary
This summary is machine-generated.

Bacterial genomics has advanced significantly, enabling detailed analysis of microbial genomes using molecular methods. This review compares techniques for mapping bacterial chromosomes and discusses emerging themes in their organization.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Advanced Quantification Methods To Improve the 18b Dormancy Model for Assessing the Activity of Tuberculosis Drugs <i>In Vitro</i>.

Antimicrobial agents and chemotherapy·2020
Same author

Antimicrobial resistance in leprosy: results of the first prospective open survey conducted by a WHO surveillance network for the period 2009-15.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2018
Same author

Mechanistic insight into mycobacterial MmpL protein function.

Molecular microbiology·2015
Same author

Genome-wide re-sequencing of multidrug-resistant Mycobacterium leprae Airaku-3.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2014
Same author

Transcriptional regulation of lipid homeostasis in mycobacteria.

Molecular microbiology·2010
Same author

Effect of serial subculturing on the genetic composition and cytotoxic activity of Mycobacterium tuberculosis.

Journal of medical microbiology·2010
Same journal

Feeding the invaders: How metabolic imbalance shapes infection and biofilm development.

FEMS microbiology reviews·2026
Same journal

Interactions between extracellular vesicles and viruses: lessons learned across species and kingdoms.

FEMS microbiology reviews·2026
Same journal

Killer Peptide: an antibody-derived self-assembling peptide bridging antimicrobial and host-defense mechanisms.

FEMS microbiology reviews·2026
Same journal

From gatekeeper to target: MAPK cascades as control circuits at the insect-microbe interface.

FEMS microbiology reviews·2026
Same journal

The role of fungal G protein-coupled receptors in interspecies cell-cell communication.

FEMS microbiology reviews·2026
Same journal

Convergent symbioses: morphology, life history, and niche specialization in coral and lichen mutualisms.

FEMS microbiology reviews·2026
See all related articles

Area of Science:

  • Microbiology
  • Genomics
  • Molecular Biology

Background:

  • Classical genetic analysis previously constrained bacterial chromosome characterization.
  • Recent decades have seen major advancements in the study of bacterial genomes.
  • New molecular techniques now allow comprehensive analysis of microbial genetic material.

Purpose of the Study:

  • To review and compare practical approaches in bacterial genomics.
  • To discuss emerging themes in bacterial chromosome structure and organization.
  • To highlight the impact of new techniques on microbial genome analysis.

Main Methods:

  • Pulsed-field gel electrophoresis of macro-restriction fragments of genomic DNA.
  • Direct molecular methods for analyzing microorganism genomes.

Related Experiment Videos

  • Construction of detailed physical and gene maps.

    • Main Results:

    • Advanced techniques have overcome limitations of classical genetic analysis.
    • It is now feasible to analyze virtually every microorganism's genome.
    • Detailed physical and gene maps can be constructed for bacterial chromosomes.

    Conclusions:

    • Bacterial genomics offers powerful tools for understanding microbial life.
    • Molecular methods provide unprecedented insights into chromosome size, shape, and organization.
    • The field is rapidly evolving, revealing new themes in bacterial genome architecture.