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Molecular cloning and expression of two horse pancreatic cDNA encoding colipase A and B
1Laboratoire de Unité de Bioénergétique et d'Ingénieric des Proteines/BIP, CNRS, Marseille, France.
Biochimica Et Biophysica Acta
|August 4, 1994
Abstract:
Pancreatic colipase plays an essential role in the intestinal fat digestion by anchoring lipase on lipid/water interfaces in the presence of bile salts. In contrast to other species, two molecular forms of colipase, A and B, have been found in horse. The two corresponding cDNAs were isolated from a horse pancreatic library and their nucleotide sequences were determined. Moreover, for the first time, active colipase has been obtained after transfection of COS cells by either colipase A or B cDNA.