[Homeostasis, diabetes and cancer]

There is a large body of evidence to consider that the functional aspects of the metabolism of the cancer cell and hypoinsulinemic diabetes mellitus dwell at both ends of a biochemico-metabolic spectrum representing two opposite homeostatic and pathological tendencies. Furthermore, an initial homeostatic approach based up the acid-base balance and/or its hydrogen ion dynamics, systematically considered at multiple dimensions of knowledge and in different areas and fields of biomedical research, allows to reach a systematic vision and an all-comprehensive and hierarchically organized perspective for the integrated study of both malignant and non-malignant, as well as diabetic, metabolism, while at the same time opens new avenues reaching out towards a better understanding of both the etiopathogenesis of certain epithelial tumors and the chronic complications of diabetes mellitus. Besides, such a unitarian outlook may very well open new ways towards a more comprehensive understanding of the interrelationships among both degenerative processes, and from the bioenergetic to the clinical levels, hopefully leading to better preventive and treatment strategies.