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Mathematical model for citric acid fermentation

J Hu1, P Wu

  • 1Beijing Institute of Fermentation Industry, China.

Chinese Journal of Biotechnology
|January 1, 1993
PubMed
Summary
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Mathematical models were developed to describe citric acid fermentation kinetics, including biomass growth and production. These models accurately predict fermentation processes, enabling optimization and computer control for improved efficiency.

Area of Science:

  • Biotechnology
  • Biochemical Engineering
  • Industrial Microbiology

Background:

  • Citric acid is a key industrial chemical produced via fermentation.
  • Understanding fermentation kinetics is crucial for process optimization.
  • Existing models may not fully capture the complex dynamics of citric acid fermentation.

Purpose of the Study:

  • To develop and validate mathematical models for citric acid fermentation kinetics.
  • To describe biomass proliferation, medium consumption, and citric acid production.
  • To provide a basis for computer-aided control and optimization of fermentation.

Main Methods:

  • Kinetic studies of biomass growth, nutrient uptake, and product formation.
  • Development of mathematical models based on experimental data.

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  • Statistical verification and parameter estimation of the models.

    • Main Results:

    • Mathematical models were successfully established for citric acid fermentation.
    • Model predictions showed excellent agreement with experimental results.
    • The models accurately represent biomass proliferation, medium consumption, and citric acid production dynamics.

    Conclusions:

    • The developed models accurately describe the course of citric acid fermentation.
    • These models are valuable tools for computer-controlled fermentation processes.
    • The findings facilitate the optimization of citric acid fermentation for industrial applications.